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Inhibition of focal adhesion kinase (FAK) rescued SERT perform in synapses of KI mice, demonstrating that constitutive active FAK signaling downstream from the Pro32Pro33 integrin αvβ3 suppresses SERT exercise. Our experiments detect a posh regulation of 5-HT homeostasis and behaviors by integrin αvβ3, revealing a vital part for integrins in mo